Investing in Innovation for Education Act of 2010

Investing in Innovation for Education Act of 2010 - Amends the Elementary and Secondary Education Act of 1965 to direct the Secretary of Education to award competitive grants to local educational agencies (LEAs) and nonprofit organizations to support the school reform efforts of public schools and LEAs.

Requires each grant applicant to demonstrate that it has partnered with at least one private organization that will provide matching funds.

Requires each grant to be used to address at least one of the following areas of school reform: (1) improving the effectiveness of teachers and school leaders and promoting their equitable distribution; (2) strengthening the use of data to improve education; (3) providing high-quality instruction that is based on rigorous standards and measuring students' proficiency using high-quality assessments that are aligned to those standards; (4) turning around the lowest-performing schools; and (5) any other area of school reform the Secretary chooses.

Directs the Secretary to establish performance measures for tracking each grantee's progress in improving the academic performance of public elementary and secondary school students, and specified subgroups of those students. Requires grantees to use grant funds to develop or expand strategies to improve high-need students' showing on those performance measures.