Health Research and Quality Act of 1999

(Sec. 2) Directs the Agency to identify and disseminate methods or systems used to assess health care research results, particularly to rate the strength of the scientific evidence behind health care practice and technology recommendations in the research.

Requires the Agency to employ research strategies and mechanisms that will link research directly with clinical practice in geographically diverse locations throughout the United States, including: (1) Health Care Improvement Research Centers that combine demonstrated multidisciplinary expertise in outcomes or quality improvement research with linkages to relevant sites of care; (2) Provider-based Research Networks, including plan, facility, or delivery system sites of care (especially primary care), that can evaluate and promote quality improvement; and (3) other innovative mechanisms or strategies.

Authorizes the Agency to provide specified scientific and technical support for private and public efforts to improve health care quality, including accrediting organizations.

Directs the Secretary, acting through the Agency Director, to establish a program of grants for one or more centers to conduct: (1) state-of-the-art research on drugs, biological products, and devices; (2) research on the comparative effectiveness, cost-effectiveness, and safety of drugs, biological products, and devices; and (3) other appropriate activities (excluding the review of new drugs).

Requires the Agency Director to: (1) collect certain data on the cost and quality of health care; (2) support research on and initiatives to advance the use of information systems for the study of health care quality; and (3) provide ongoing administrative, research, and technical support for the Preventive Services Task Force, which shall review scientific evidence on the effectiveness, appropriateness, and cost-effectiveness of clinical preventive services regarding their usefulness in daily clinical practice.

Establishes within the Agency a Center for Primary Care Research to serve as the principal funding source for Department of Health and Human Services primary care delivery research and demonstrations with respect to the first contact when illness or health concerns arise, the diagnosis, treatment or referral to specialty care, preventive care, and the relationship between the clinician and the patient in the context of the family and community.

Requires the Agency Director by specified activities to promote innovation in evidence-based clinical practice and health care technologies.

Requires the Secretary, acting through the Director, to coordinate all research, evaluations, and demonstrations related to health services research and quality measurement and improvement activities undertaken and supported by the Federal Government. .

Establishes an Advisory Council for Health Care Research and Quality to replace the current Advisory Council for Health Care Policy, Research, and Evaluation.

Requires the Agency Director to establish technical and scientific peer review groups to review each application for a grant, cooperative agreement, or contract under the provisions of this Act relating to the new Agency and its mission and duties.

Repeals the mandates for: (1) a demonstration program regarding centers for education and research on therapeutics; and (2) the Office of the Forum for Quality and Effectiveness in Health Care.

Authorizes appropriations.

(Sec. 3) Directs the Secretary, acting through appropriate PHS agencies, to make grants to public or nonprofit private entities for the establishment and operation of regional centers to identify particular populations of patients and facilitate appropriate patient utilization of preventive health services through developing and disseminating strategies to improve the methods used by public and private health care programs and providers in interacting with such patients. Requires applicant entities to meet certain requirements with regard to quality management in order to be eligible to receive such a grant. Authorizes appropriations.